Speakers - CWC 2023

Abstract

Background: Obesity, hyperglycemia, dyslipidemia, and hypertension are important components of the metabolic syndrome (MetS), which are related to an increased breast cancer (BC) risk among overweight and obese women. Thus, our study aimed to investigate the relationship between MetS components and BC risk and whether the different components act as plausible biomarkers for BC risk. Patients and Methods: A total of sixty-nine (69) Yemeni women diagnosed with BC (mean ages: 48.17 ± 11.0 years) were recruited from the Hadhramout National Oncology Center, Yemen, and participated in a cross-sectional study from 1st March to 30th June 2021. Metabolic syndrome with measures of adiposity (BMI, WC, HC, WH ratio), blood pressure, FBG, HbA1c, total cholesterol, triglycerides, HDL-C, LDLC, CRP, and insulin were measured. HOMA-IR was calculated to assess insulin resistance (IR). Results: More than half of the participants had BC stage II (53%), and the remaining had stage III (22%), and stage IV (25%). Our findings showed that SBP (OR= 1.058, 95%CI= 1.007-1.111, p= 0.025), total cholesterol (OR= 1.023, 95%CI= 1.007-1.039, p= 0.004), and LDL-C (OR= 1.023, 95%CI= 1.006-1.041, p= 0.009) were significantly correlated with increased BC risk in overweight and obese patients. Moreover, BMI (OR= 1.078, 95%CI = 1.006-1.155, p= 0.033) and HbA1c (OR= 1.868, 95%CI= 1.100-3.171, p= 0.021) were significantly correlated with increased BC risk in hypertensive patients. Conclusion: Our findings observed increased trends between BMI, SBP, HbA1c, total cholesterol, and LDL-C among Yemeni women with BC, suggesting that obesity, dyslipidemia, and hypertension have been widely considered to be linked with the initiation and progression of BC. Thus, these findings give us further evidence for these components as plausible biomarkers of increased BC risk.