Chunyang Jiang, Medical Ph.D., Research on the mechanism and target therapy of lung cancer; Research on mechanism in invasion and metastasis of lung adenocarcinoma, especially on the expression profile of long non-coding RNA in lung adenocarcinoma and its relations in metastasis of lung adenocarcinoma; Emphasized exosome’s function in the TME for tumor metastasis. Have published almost 40 articles about cancer.
As an important medium of intercellular communication, exosomes play an important role in information transmission between tumor cells and their microenvironment. Tumor metastasis is a serious influencing factor for poor treatment effects and shortened survival. Lung cancer is a major malignant tumor that seriously threatens human health. The study of the underlying mechanisms of exosomes in tumor genesis and development may provide new ideas for early and effective diagnosis and treatment of lung cancer metastasis. Many studies have shown that tumor-derived exosomes promote lung cancer development through a number of processes. By promoting the epithelial-mesenchymal transition of tumor cells, they induce angiogenesis, the establishment of the pretransfer microenvironment, and immune escape. This understanding enables researchers to better understand the mechanism of lung cancer metastasis and explore new treatments for clinical application. In this article, we systematically review the current research progress of tumor-derived exosomes in lung cancer metastasis. Although positive progress has been made toward understanding the mechanism of exosomes in lung cancer metastasis, systematic basic research and clinical translational research remain lacking and are needed to translate our scientific understanding toward applications in the clinical diagnosis and treatment of lung cancer metastasis in the near future.