2ⁿᵈ Edition of the Cancer R&D World Conference 2026

Abstract

Introduction: Hematologic malignancies remained a major global public health issue and the leading cause of global tumor burden. It significantly affects patients' overall health-related quality of life, financial toxicity, physical distress, and mental health challenges. So this study is aimed to estimate burden of bone marrow confirmed malignant hematological disorders in patients with abnormal hematological parameter.

Method And Materials: Both manual and electronic searches were used to extract studies for this meta-analysis from PubMed, Google Scholar, Scopus, DOAJ, Web of Science, and Google databases were utilized to identify the eligible articles. Then identified articles were exported into EndNote software used to export, organize, and review, the eligible articles. The quality of studies was assessed by using the Newcastle-Ottawa Scale quality appraisal tool for prevalence study. Meta-analysis was carried out using a random-effects method using the STATA™ Version 14 software.

Result: Nine included studies with a total of 31, 564 participants enrolled in this study. According to this study the pooled proportion of malignant hematological disorders in Ethiopia was found to be 8.47% (95% CI: 5.28-11.65) with range of 2.8%-17.2%. The highest prevalence of hematological malignancy is 11.92 % (95% CI: 4.30- 19.54) was seen in northern region, and the lowest is 5.82 % (95% CI: 1.78.-9.86) was seen in central region.

Conclusion: According to these findings the pooled prevalence of malignant hematological disorders substantial in Ethiopia. Also, the findings highlight marked geographic disparities. So strengthening of hematologic diagnostic and treatment services are essential to ensure earlier detection and better management of hematologic malignancies across the country. Keywords: hematologic malignancies; ethiopia; bone marrow; meta-analysis; hematological parameter