2ⁿᵈ Edition of the Cancer R&D World Conference 2026

Abstract

Breast cancer is a multifaceted disease characterized by uncontrolled proliferation, the spread of cancer cells to other parts of the body, and intermittent occurrence. Triple-negative breast cancer (TNBC) is one of the highly aggressive subtypes of breast cancer with limited treatment options and poor prognosis, resulting in high mortality rates worldwide. Conventional cancer therapies often have damaging side effects, which has led to the search for alternative therapeutic strategies. Natural plant compounds, known as phytochemicals, have shown potential in reducing the aggressive characteristics of various cancer types. These compounds target key regulators of the glycolytic pathway, such as hexokinases, glucose transporters, pyruvate kinase, and lactate dehydrogenase, and disrupt HIF-1 synthesis, stabilization, accumulation, and transactivation via the PI3K/Akt/mTOR and MAPK/ERK signaling pathways.  

Cell migration is a critical process driving metastasis progression in triple-negative breast cancer which makes breast cancer metastasis a significant challenge in cancer treatment, often associated with altered metabolic pathways such as the Warburg effect.  This study investigated the potential of combining quercetin and vorinostat (SAHA) with epigenetic properties to prevent breast cancer metastasis by targeting the Warburg effect and inhibiting the migration of metastatic TNBC cells. To achieve this, we carried out a comprehensive research plan involving metabolite extraction, enzymatic assay, proteomics, and gene expression analysis.