Tumour suppressor molecules are critical in regulating cell growth and preventing malignancies. In cancer therapy, strategies aim to restore or mimic the function of these molecules, such as p53 and RB, which are often inactivated in tumors. At the Cancer Research and Development Conference 2025, experts will present advances in gene therapy, small molecules, and targeted delivery systems that enable tumour suppressors' reactivation. These promising avenues aim to inhibit cancer progression and improve therapeutic outcomes, offering a novel approach to cancer treatment.