Systems biology integrates computational and experimental approaches to understand the complex interactions within cancer at a molecular and cellular level. It uncovers key pathways driving tumour development and progression by analysing large datasets, such as genomic, proteomic, and metabolomic information. At the Cancer Research and Development Conference 2025, this session will explore how this holistic approach enables the identification of novel biomarkers, therapeutic targets, and resistance mechanisms, advancing precision oncology and personalized treatment strategies.